Agios Nikolaos or Aghios Nikolaos (Greek: Άγιος Νικόλαος [ˈaʝos niˈkolaos]) is a coastal town on the Greek island of Crete, lying east of the island's capital Heraklion, north of the town of Ierapetra and west of the town of Sitia.
In the year 2011, the Municipality of Agios Nikolaos, which takes in part of the surrounding villages, claimed 27,074 inhabitants. The town is a municipality of the Crete region and sits partially upon the ruins of the ancient city of Lato pros Kamara.